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Anticancer Res. 2016 Oct;36(10):5333-5337.

Pro-inflammatory State Portends Poor Outcomes with Stereotactic Radiosurgery for Brain Metastases.

Author information

1
Department of Radiation Oncology, University of California Los Angeles, Los Angeles, CA, U.S.A.
2
Department of Neurosurgery, University of California Los Angeles, Los Angeles, CA, U.S.A.
3
Department of Radiation Oncology, University of California Los Angeles, Los Angeles, CA, U.S.A. TKaprealian@mednet.ucla.edu.

Abstract

AIM:

We determined if pre-treatment systemic inflammation would predict poor outcomes in the setting of stereotactic radiosurgery (SRS) for brain metastases.

PATIENTS AND METHODS:

The pretreatment albumin concentration, neutrophil and lymphocyte counts, and the platelet-to-lymphocyte ratio (PLR) were evaluated to determine association with intracranial control, local control (LC), initial MRI response (MR), and overall survival (OS) among 70 patients with 152 separate brain metastases treated with SRS alone from 2008-2015.

RESULTS:

On multivariate analysis, a higher neutrophil percentage predicted for poor LC, poor initial MR, poor OS and poor intracranial control (p=0.01, p=0.01, p=0.02 and p=0.03, respectively). A lower percentage of lymphocytes predicted for poor LC and poor MR (p=0.01 and p=0.02), and an elevated PLR predicted for poor OS and poor LC (p=0.05 and p=0.04). Additionally, a lower pretreatment albumin concentration predicted for poor LC and OS (p=0.01 and p=0.03).

CONCLUSION:

Pretreatment systemic inflammation is associated with poor outcomes post-SRS.

KEYWORDS:

Brain metastases; SRS; immune responses; inflammation; radiosurgery

PMID:
27798896
DOI:
10.21873/anticanres.11106
[Indexed for MEDLINE]

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