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Nat Genet. 2016 Dec;48(12):1557-1563. doi: 10.1038/ng.3708. Epub 2016 Oct 31.

Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.

Author information

1
University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
2
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
3
23andMe, Inc., Mountain View, California, USA.
4
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
5
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
6
School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
7
Department of Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
8
NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK.
9
University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands.
10
Durrer Center for Cardiogenetic Research, Netherlands Heart Institute, Utrecht, the Netherlands.

Abstract

Resting heart rate is a heritable trait correlated with life span. Little is known about the genetic contribution to resting heart rate and its relationship with mortality. We performed a genome-wide association discovery and replication analysis starting with 19.9 million genetic variants and studying up to 265,046 individuals to identify 64 loci associated with resting heart rate (P < 5 × 10-8); 46 of these were novel. We then used the genetic variants identified to study the association between resting heart rate and all-cause mortality. We observed that a genetically predicted resting heart rate increase of 5 beats per minute was associated with a 20% increase in mortality risk (hazard ratio 1.20, 95% confidence interval 1.11-1.28, P = 8.20 × 10-7) translating to a reduction in life expectancy of 2.9 years for males and 2.6 years for females. Our findings provide evidence for shared genetic predictors of resting heart rate and all-cause mortality.

PMID:
27798624
DOI:
10.1038/ng.3708
[Indexed for MEDLINE]

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