Send to

Choose Destination
Environ Sci Pollut Res Int. 2017 Jan;24(2):1700-1705. doi: 10.1007/s11356-016-7946-9. Epub 2016 Oct 29.

The effect of probiotic bacteria (Lactobacillus acidophilus and Bifidobacterium lactis) on the accumulation of lead in rat brains.

Author information

Department of Food Safety and Hygiene, School of Health, Zanjan University of Medical Science, Zanjan, Iran.
Department of Toxicology, School of Pharmacy, Zanjan University of Medical Science, Zanjan, Iran.
Department of Food and Drug Control, School of Pharmacy, Zanjan University of Medical Science, Zanjan, Iran.


Lead is a toxic metal present in different concentrations in a wide variety of food products. Exposure to lead, even to low levels, causes acute and chronic toxicities. Lead can cross the blood-brain barrier and accumulate in the nervous system. Probiotics are live microorganisms that, when used in adequate amounts, confer a health benefit on the host. Although a recent study demonstrated that the studied bacteria have a protective effect against acute lead toxicity, no research has been found that shows the long-term impact of these bacteria in vivo. The current study surveyed the protective effects of two species of probiotics, Lactobacillus acidophilus LA-5 and Bifidobacterium lactis BB-12, that are most widely used in many functional foods against oral lead exposure (4 weeks) in rat brains. The results revealed that, at the end of the second week of chronic exposure to lead and probiotic bacteria, the lowest level of lead belonged to the Lactobacillus group. At the end of the fourth week, the lowest amount of lead was related to the group receiving both types of probiotics. With the physiological benefits of probiotic consumption, the bacterial solution in this study did not show high efficacy in reducing brain lead concentrations.


Bifidobacterium lactis; Brain; Lactobacillus acidophilus; Lead; Probiotic

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center