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J Clin Microbiol. 2017 Feb;55(2):360-368. doi: 10.1128/JCM.01057-16. Epub 2016 Oct 19.

Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases.

Author information

1
Duke University School of Medicine, Duke University, Durham, North Carolina, USA.
2
Center for Applied Genomics and Precision Medicine, Duke University, Durham, North Carolina, USA.
3
Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA.
4
Emergency Medicine Service, Durham Veteran's Affairs Medical Center, Durham, North Carolina, USA.
5
Section for Infectious Diseases, Medicine Service, Durham Veteran's Affairs Medical Center, Durham, North Carolina, USA.
6
Center for Applied Genomics and Precision Medicine, Duke University, Durham, North Carolina, USA micah.mcclain@duke.edu.

Abstract

Emerging pandemic infectious threats, inappropriate antibacterial use contributing to multidrug resistance, and increased morbidity and mortality from diagnostic delays all contribute to a need for improved diagnostics in the field of infectious diseases. Historically, diagnosis of infectious diseases has relied on pathogen detection; however, a novel concept to improve diagnostics in infectious diseases relies instead on the detection of changes in patterns of gene expression in circulating white blood cells in response to infection. Alterations in peripheral blood gene expression in the infected state are robust and reproducible, yielding diagnostic and prognostic information to help facilitate patient treatment decisions.

KEYWORDS:

diagnostics; gene expression

PMID:
27795332
PMCID:
PMC5277504
DOI:
10.1128/JCM.01057-16
[Indexed for MEDLINE]
Free PMC Article

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