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Trends Plant Sci. 2016 Dec;21(12):1034-1044. doi: 10.1016/j.tplants.2016.09.003. Epub 2016 Oct 25.

miRNA Biogenesis: A Dynamic Pathway.

Author information

1
Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Bioquímica y Ciencias Biológicas (FBCB), Universidad Nacional del Litoral (UNL), Paraje El Pozo, 3000 Santa Fe, Argentina.
2
Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Bioquímica y Ciencias Biológicas (FBCB), Universidad Nacional del Litoral (UNL), Paraje El Pozo, 3000 Santa Fe, Argentina. Electronic address: pablomanavella@ial.santafe-conicet.gov.ar.

Abstract

MicroRNAs (miRNAs) modulate plant homeostasis through the inactivation of specific mRNAs, especially those encoding transcription factors. A delicate spatial/temporal balance between a miRNA and its targets is central to achieving the appropriate biological outcomes. In this review we discuss our growing understanding of the dynamic regulation of miRNA biogenesis. We put special emphasis on crosstalk between miRNA biogenesis and other cellular processes such as transcription and splicing. We also discuss how the pathway is regulated in specific tissues to achieve harmonious plant development through a subtle balance between gene expression and silencing.

KEYWORDS:

gene silencing; miRNA biogenesis; microRNA; small RNA; splicing.

PMID:
27793495
DOI:
10.1016/j.tplants.2016.09.003
[Indexed for MEDLINE]

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