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Fertil Steril. 2017 Jan;107(1):74-82.e7. doi: 10.1016/j.fertnstert.2016.09.015. Epub 2016 Oct 25.

Clinical, genetic, biochemical, and testicular biopsy findings among 1,213 men evaluated for infertility.

Author information

1
Department of Growth and Reproduction, International Research and Research Training Center in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address: iao@dadlnet.dk.
2
Department of Growth and Reproduction, International Research and Research Training Center in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
3
Department of Clinical Genetics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Abstract

OBJECTIVE:

To study the pathologic findings among men evaluated for infertility.

DESIGN:

A retrospective, single-center, cross-sectional study.

SETTING:

University hospital-based research center.

PARTICIPANT(S):

We included data from 1,213 medical records from infertile men referred for diagnostic work-up from 2005 to 2009.

INTERVENTIONS(S):

None.

MAIN OUTCOME MEASURE(S):

Health history, clinical findings, chromosome/genetic aberrations, semen quality, reproductive hormones.

RESULT(S):

In total, 64.4% of the infertile men had one or more reproductive disorders or factors influencing fertility, leaving 35.6% diagnosed as idiopathic infertile. In 244 patients (20%), including seven cases of testicular cancer and/or germ cell neoplasia in situ, a pathologic finding was first detected during diagnostic work-up. Two hundred four patients (16.8%) had a history of cryptorchidism and 154 (12.7%) of varicocele (grade 2 and 3). Thirty-three patients had chromosomal abnormalities, including 16 with sex chromosome abnormalities (11 with 47,XXY). Y-chromosome microdeletions were detected in 65 patients (5.4%). One hundred thirty-three had azoospermia, of which 58 had testicular biopsy findings (Sertoli cell-only syndrome: n = 23; spermatogenic arrest: n = 7; impaired spermatogenesis and atrophy: n = 28). Additionally, in idiopathic infertile men and infertile men with additional symptoms of testicular dysgenesis syndrome, 22.5% presented with a degree of Leydig cell insufficiency, with the highest frequency (33.1%) among patients with sperm concentration <5 million/mL.

CONCLUSION(S):

We report pathologic findings that could explain the male-factor infertility in two-thirds of infertile men referred to our center. Thus, male infertility may be a sign of an underlying disease that warrants attention.

KEYWORDS:

Male infertility; Y-chromosome microdeletions; chromosome abnormalities; testicular cancer; testicular dysgenesis syndrome (TDS)

[Indexed for MEDLINE]

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