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Scand J Trauma Resusc Emerg Med. 2016 Oct 28;24(1):129.

Myocardial function at the early phase of traumatic brain injury: a prospective controlled study.

Author information

1
Pôle Anesthésie Réanimation, Hôpital Albert Michallon, BP 217, Centre Hospitalier Universitaire de Grenoble, CS 10217, F-38043, Grenoble, France.
2
Laboratory of Integrative Cardiovascular and Metabolic Physiology, Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland.
3
Grenoble Institut des Neurosciences, INSERM U1216, F-38043, Grenoble, France.
4
Grenoble Alpes Université, F-38043, Grenoble, France.
5
Avignon University, LAPEC EA4278, F-84000, Avignon, France.
6
Pôle Anesthésie Réanimation, Hôpital Albert Michallon, BP 217, Centre Hospitalier Universitaire de Grenoble, CS 10217, F-38043, Grenoble, France. PBouzat@chu-grenoble.fr.
7
Grenoble Institut des Neurosciences, INSERM U1216, F-38043, Grenoble, France. PBouzat@chu-grenoble.fr.
8
Grenoble Alpes Université, F-38043, Grenoble, France. PBouzat@chu-grenoble.fr.

Abstract

BACKGROUND:

The concept of brain-heart interaction has been described in several brain injuries. Traumatic brain injury (TBI) may also lead to cardiac dysfunction but evidences are mainly based upon experimental and clinical retrospective studies.

METHODS:

We conducted a prospective case-control study in a level I trauma center. Twenty consecutive adult patients with severe TBI were matched according to age and gender with 20 control patients. The control group included adult patients undergoing a general anesthesia for a peripheral trauma surgery. Conventional and Speckle Tracking Echocardiography (STE) was performed within the first 24 post-traumatic hours in the TBI group and PRE/PER-operative in the control group. The primary endpoint was the left ventricle ejection fraction (LVEF) measured by the Simpson's method. Secondary endpoints included the diastolic function and the STE analysis.

RESULTS:

We found similar LVEF between the TBI group and the PER-operative control group (61 % [56-76]) vs. 62 % [52-70]). LV morphological parameters and the systolic function were also similar between the two groups. Regarding the diastolic function, the isovolumic relaxation time was significantly higher in the TBI cohort (125 s [84-178] versus 107 s [83-141], p = 0.04), suggesting a subclinical diastolic dysfunction. Using STE parameters, we observed a trend toward higher strains in the TBI group but only the apical circumferential strain and the basal rotation reached statistical significance. STE-derived parameters of the diastolic function tended to be lower in TBI patients.

DISCUSSION:

No systematic myocardial depression was found in a cohort of severe TBI patients.

CONCLUSIONS:

STE revealed a correct adaptation of the left systolic function, while the diastolic function slightly impaired.

TRIAL REGISTRATION:

NCT02380482.

PMID:
27793208
PMCID:
PMC5084439
DOI:
10.1186/s13049-016-0323-3
[Indexed for MEDLINE]
Free PMC Article

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