Format

Send to

Choose Destination
See comment in PubMed Commons below
Oncotarget. 2016 Nov 15;7(46):74510-74525. doi: 10.18632/oncotarget.12903.

Long-term exposure to air pollution is associated with biological aging.

Author information

  • 1Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Bavaria, Germany.
  • 2Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • 3Research Unit Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Bavaria, Germany.
  • 4Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
  • 5Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA.
  • 6Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel.
  • 7Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • 8VA Normative Aging Study, Veterans Affairs Boston Healthcare System and the Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Abstract

Long-term exposure to air pollution is associated with age-related diseases. We explored the association between accelerated biological aging and air pollution, a potential mechanism linking air pollution and health. We estimated long-term exposure to PM10, PM2.5, PM2.5 absorbance/black carbon (BC), and NOx via land-use regression models in individuals from the KORA F4 cohort. Accelerated biological aging was assessed using telomere length (TeloAA) and three epigenetic measures: DNA methylation age acceleration (DNAmAA), extrinsic epigenetic age acceleration (correlated with immune cell counts, EEAA), and intrinsic epigenetic age acceleration (independent of immune cell counts, IEAA). We also investigated sex-specific associations between air pollution and biological aging, given the published association between sex and aging measures. In KORA an interquartile range (0.97 µg/m3) increase in PM2.5 was associated with a 0.33 y increase in EEAA (CI = 0.01, 0.64; P = 0.04). BC and NOx (indicators or traffic exposure) were associated with DNAmAA and IEAA in women, while TeloAA was inversely associated with BC in men. We replicated this inverse BC-TeloAA association in the Normative Aging Study, a male cohort based in the USA. A multiple phenotype analysis in KORA F4 combining all aging measures showed that BC and PM10 were broadly associated with biological aging in men. Thus, we conclude that long-term exposure to air pollution is associated with biological aging measures, potentially in a sex-specific manner. However, many of the associations were relatively weak and further replication of overall and sex-specific associations is warranted.

KEYWORDS:

Gerotarget; air pollution; biological aging; black carbon; epigenetic aging; telomere length

PMID:
27793020
DOI:
10.18632/oncotarget.12903
[PubMed - in process]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Impact Journals, LLC
    Loading ...
    Support Center