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J Neurosurg. 2017 Oct;127(4):775-780. doi: 10.3171/2016.8.JNS16467. Epub 2016 Oct 28.

Safety and efficacy of the Pipeline embolization device for treatment of intracranial aneurysms: a pooled analysis of 3 large studies.

Author information

1
Department of Radiology, Mayo Clinic, Rochester, Minnesota.
2
Koru Hospital and Bayindir Hospitals, Ankara, Turkey; and.
3
Department of Neurosurgery, Cerebrovascular Center, Stony Brook University Medical Center, Stony Brook.
4
Stroke and Cerebrovascular Surgery, Lyerly Neurosurgery/Baptist Neurological Institute, Jacksonville, Florida.
5
Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
6
Department of Neurological Surgery, Rush University Medical Center, Chicago, Illinois.
7
Department of Neurosurgery, ENERI-Clinica La Sagrada Familia, Buenos Aires, Argentina.
8
Department of Endovascular Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona.
9
Department of Neurosurgery, University at Buffalo Neurosurgery, Buffalo, New York.

Abstract

OBJECTIVE The authors performed a pooled analysis of 3 studies-IntrePED (International Retrospective Study of the Pipeline Embolization Device), PUFS (Pipeline for Uncoilable or Failed Aneurysms Study), and ASPIRe (Aneurysm Study of Pipeline in an Observational Registry)-in order to assess angiographic outcomes and clinical safety of the Pipeline embolization device (PED). METHODS IntrePED was a retrospective study, while PUFS and ASPIRe were prospective studies. For each patient included in these studies, the authors collected baseline demographic data, aneurysm characteristics, and procedural details. The primary outcomes for this combined analysis were clinical outcomes, including neurological morbidity and mortality and major ipsilateral intracranial hemorrhage and ischemic stroke. The secondary outcomes were angiographic occlusion rates, which were available for ASPIRe and PUFS only. RESULTS A total of 1092 patients with 1221 aneurysms were included across the 3 studies. The mean aneurysm size was 12.0 ± 7.8 mm and the mean neck size was 6.6 ± 4.8 mm. The major ipsilateral ischemic stroke rate was 3.7% (40/1091). The major ipsilateral intracranial hemorrhage rate was 2.0% (22/1091). The major neurological morbidity rate was 5.7% (62/1091). The neurological mortality rate was 3.3% (36/1091). The combined major morbidity and neurological mortality rate was 7.1% (78/1091). The complete occlusion rates were 75.0% at 180 days (111/148) and 85.5% at 1 year (94/110). The overall aneurysm retreatment rate was 3.0% (33/1091) at a mean follow-up time of 10.2 ± 10.8 months. CONCLUSIONS Endovascular treatment of intracranial aneurysms with the PED is safe and effective. Angiographic occlusion rates progressed with follow-up. Rates of stroke, hemorrhage, morbidity and mortality, and retreatment were low, especially given the fact that the aneurysms treated were generally large and wide necked.

KEYWORDS:

ASPIRe = Aneurysm Study of Pipeline in an Observational Registry; ICA = internal carotid artery; IQR = interquartile range; IntrePED = International Retrospective Study of the Pipeline Embolization Device; PED = Pipeline embolization device; PUFS = Pipeline for Uncoilable or Failed Aneurysms Study; aneurysm; endovascular; interventional neurosurgery; stroke; vascular disorders

PMID:
27791519
DOI:
10.3171/2016.8.JNS16467
[Indexed for MEDLINE]

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