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J Dermatol. 2017 Mar;44(3):339-342. doi: 10.1111/1346-8138.13641. Epub 2016 Oct 28.

Two cases of seborrheic keratosis with basal clear cells.

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Sapporo Institute for Dermatopathology, Sapporo, Japan.


Seborrheic keratosis with basal clear cells (SKBCC) is an extremely rare histopathological variant of seborrheic keratosis that has histological similarities to melanoma in situ. We herein report two cases of SKBCC and provide the first description of the dermoscopic features of this condition, in addition to the histopathological findings. Both of the two lesions showed typical histological architectures of seborrheic keratosis with rows or focal clusters of monomorphic clear cells with abundant pale cytoplasm and small round nucleus in the basal layer. Immunohistochemical examination revealed that most clear cells were positive for high molecular weight cytokeratin (34βE12) in a peripheral pattern but were negative tor Melan-A. Dermoscopy revealed typical features of ordinary seborrheic keratosis, while unfortunately did not reflect the presence of basal clear cells.


34βE12; Melan-A; dermoscopy; histopathology; seborrheic keratosis with basal clear cells

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