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Aliment Pharmacol Ther. 2017 Jan;45(1):160-168. doi: 10.1111/apt.13821. Epub 2016 Oct 28.

Hepatocellular carcinoma recurrence in patients with curative resection or ablation: impact of HCV eradication does not depend on the use of interferon.

Author information

1
Palermo, Italy.
2
Bologna, Italy.
3
Padova, Italy.
4
Genoa, Italy.
5
Zingonia, Italy.
6
Rome, Italy.
7
Seriate, Italy.
8
Viterbo, Italy.
9
Milan, Italy.
10
Pisa, Italy.
11
Florence, Italy.
12
Bolzano, Italy.
13
Naples, Italy.
14
Ancona, Italy.
15
Faenza, Italy.
16
Parma, Italy.
17
Negrar, Italy.
18
Salerno, Italy.
19
Rozzano, Italy.

Abstract

BACKGROUND:

In HCV-infected cirrhotic patients with successfully treated early hepatocellular carcinoma (HCC), the time to HCC recurrence and the effects of sustained viral eradication (SVR) by interferon (IFN)-based or IFN-free regimens on HCC recurrence remain unclear.

AIM:

To perform an indirect comparison of time to recurrence (TTR) in patients with successfully treated early HCC and active HCV infection with those of patients with SVR by IFN-based and by IFN-free regimens.

METHODS:

We evaluated 443 patients with HCV-related cirrhosis and Barcelona Clinic Liver Cancer Stage A/0 HCC who had a complete radiological response after curative resection or ablation. Active HCV infection was present in 328, selected from the Italian Liver Cancer group cohort; 58 patients had SVR achieved by IFN-free regimens after HCC cure, and 57 patients had SVR achieved by IFN-based regimens after HCC cure. Individual data of patients in the last two groups were extracted from available publications.

RESULTS:

TTR by Kaplan-Meier curve was significantly lower in patients with active HCV infection compared with those with SVR both by IFN-free (P = 0.02) and by IFN-based (P < 0.001) treatments. TTR was similar in patients with SVR by IFN-free or by IFN-based (P = 0.49) strategies.

CONCLUSION:

In HCV-infected, successfully treated patients with early HCC, SVR obtained by IFN-based or IFN-free regimens significantly reduce tumour recurrence without differences related to the anti-viral strategy used.

PMID:
27790734
DOI:
10.1111/apt.13821
[Indexed for MEDLINE]
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