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J Nutr Med Diet Care. 2016;2(1). pii: 11. Epub 2016 Mar 22.

The Extraction, Anticancer Effect, Bioavailability, and Nanotechnology of Baicalin.

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College of Science, Technology & Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA.


The dried root of Baikal skullcap (Scutellaria baicalensis) has been historically and widely used in traditional Eastern medicine. Modern science proved that baicalin is the major bioactive responsible for the physiological activity of Baikal skullcap. Baicalin, a flavonoid found in several species in the genus Scutellaria, has been regarded as a potent anticancer agent. In this review, we present the main extraction methods, anticancer activity and bioavailability of baicalin. Besides, the utilization of nanotechnology to improve the bioavailability of baicalin is also mentioned.


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