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J Clin Diagn Res. 2016 Sep;10(9):FF11-FF15. Epub 2016 Sep 1.

Comparison between the Effect of Cow Ghee and Butter on Memory and Lipid Profile of Wistar Rats.

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Associate Professor, Department of Pharmacology, SKN Medical College , Pune, Maharashtra, India .
Student, BVDU Medical College , Pune, Maharashtra, India .
Resident, Department of Pharmacology, BVDU Medical College , Pune, Maharashtra, India .



The traditional texts designate Cow Ghee as Medhya Rasayana, beneficial for mental alertness and memory. There has been concern about increased risk of cardiovascular disease due to its high percentage of saturated fatty acids in ghee. Amongst all edible fats, nutrition composition of cow ghee and butter is comparatively similar. Hence we had planned a study to assess effect of cow ghee on memory and lipid profile.


So the aim of this study is to assess the effect of cow ghee on memory and lipid profile.


Nootropic activity of test drugs was assessed by Elevated Plus Maze (EPM) and Morris Water Maze (MWM) model. Rats were divided into four groups namely control, Piracetam, cow ghee and butter. All drugs were given orally for 21 days. Transfer latency was measured in EPM model and probe test was done in MWM model.


Cow ghee and butter group showed no significant effect on memory in EPM and MWM model. There was reduction in weight of animals in Cow Ghee group and increase in weight with Butter. In both the models there was a significant increase in Triglyceride (TG) and Very Low Density Lipoproteins (VLDL) levels of rats in butter groups and increase in TG and VLDL of rats with cow ghee in EPM model.


The result of experiment suggests that no beneficial effect cow ghee and butter on cognition was seen. However, ghee is relatively safer when compared to Butter in considering lipid profile.


Cholesterol; Docosahexaenoic acid; Elevated plus maze; Goghruta; Morris water maze; Nootropic activity; Polyunsaturated fatty acids

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