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Oncotarget. 2017 Feb 7;8(6):10650-10661. doi: 10.18632/oncotarget.12890.

Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma.

Wang SS1,2, Cen X1,2, Liang XH1,2, Tang YL1,3.

Author information

1
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu Sichuan, People's Republic of China.
2
Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu Sichuan, People's Republic of China.
3
Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu Sichuan, People's Republic of China.

Abstract

Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, has been showed to be associated with the immunopathogenesis of many diseases. Recent study demonstrated that MIF promoted tumorigenesis and tumor progression and played a critical role in various kinds of human cancer including head and neck squamous cell carcinoma(HNSCC). Hence, in this paper we retrospected the relationship between MIF and angiogenesis, epithelial-mesenchymal transition (EMT), inflammation, immune response, hypoxia microenvironment, and discussed whether it is a promising biomarker for diagnosis and supervisor of HNSCC.

KEYWORDS:

biomarker; head and neck squamous cell carcinoma; macrophage migration inhibitory factor; metastasis; tumorigenesis

PMID:
27788497
PMCID:
PMC5354689
DOI:
10.18632/oncotarget.12890
[Indexed for MEDLINE]
Free PMC Article

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