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Semin Immunopathol. 2017 Apr;39(3):295-305. doi: 10.1007/s00281-016-0597-6. Epub 2016 Oct 27.

Myeloid-derived suppressor cells and tumor escape from immune surveillance.

Author information

1
Skin Cancer Unit, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. v.umansky@dkfz.de.
2
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, 68167, Mannheim, Germany. v.umansky@dkfz.de.
3
Skin Cancer Unit, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
4
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, 68167, Mannheim, Germany.

Abstract

Tumor progression is known to be supported by chronic inflammatory conditions developed in the tumor microenvironment. It is characterized by the long-term secretion of various inflammatory soluble factors (including cytokines, chemokines, growth factors, reactive oxygen and nitrogen species, prostaglandins, etc.) and strong leukocyte infiltration. Among leukocytes infiltrating tumors, myeloid-derived suppressor cells (MDSCs) represent one of the most important players mediating immunosuppression and supporting tumor escape. These cells can strongly inhibit antitumor immune reactions mediated by T cells and NK cells. Moreover, MDSCs are generated, recruited to the tumor site, and activated not only under the influence of soluble inflammatory mediators but also due to extracellular vesicles (EVs) secreted by tumor cells. EVs play a key role in the formation of MDSCs via the conversion of normal myeloid cells and altering the normal myelopoiesis. In addition, EVs help create a suitable microenvironment for the metastatic process.

KEYWORDS:

Cancer; Chronic inflammatory factors; Extracellular microvesicles; Immunosuppression; Myeloid-derived suppressor cells; Tumor microenvironment

PMID:
27787613
DOI:
10.1007/s00281-016-0597-6
[Indexed for MEDLINE]

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