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Adv Mater. 2016 Dec;28(48):10613-10622. doi: 10.1002/adma.201603095. Epub 2016 Oct 27.

Esterase-Activated Charge-Reversal Polymer for Fibroblast-Exempt Cancer Gene Therapy.

Author information

1
Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
2
Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Abstract

Selective gene expression in tumors via responsive dissociation of polyplexes triggered by intracellular signals is demonstrated. An esterase-responsive charge-reversal polymer mediates selective gene expression in the cancer cells high in esterases over fibroblasts low in esterase activity. Its gene therapy with the TRAIL suicide gene effectively induces apoptosis of HeLa cells but does not activate fibroblasts to secrete WNT16B, enabling potent cancer gene therapy with few side effects.

KEYWORDS:

cancer gene therapy; charge-reversal polymer; esterase-responsive; fibroblast exempt; intraperitoneal tumors

PMID:
27786373
DOI:
10.1002/adma.201603095
[Indexed for MEDLINE]

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