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Onco Targets Ther. 2016 Oct 11;9:6203-6210. eCollection 2016.

miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer.

Author information

1
Department of Pathology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China.

Abstract

Breast cancer is the second leading cause of cancer mortality in women worldwide. Molecular therapy is needed to improve the outcome in patients with breast cancer. miR-203 participates in cancer cell proliferation, transformation, and apoptosis. This study showed that miR-203 was upregulated in breast cancer tissues and the MCF-7 cell line. miR-203 knockdown suppressed colony formation and transformation and also limited migration in MCF-7 cells. Fibroblast growth factor 2 (FGF2) was confirmed as a novel target of miR-203, as miR-203 knockdown induced an enhanced expression of FGF2 in MCF-7 cells. Moreover, FGF2 can reverse transforming growth factor-β signal pathway to suppress breast cancer. These findings provide new insights with potential therapeutic applications for the treatment of breast cancer.

KEYWORDS:

FGF2; breast cancer; miR-203

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