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J Immunol. 1989 Sep 15;143(6):1822-5.

Two better cell lines for making hybridomas expressing specific T cell receptors.

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1
Howard Hughes Medical Institute, Department of Pediatrics, Denver, CO.

Abstract

Two variants of the AKR thymoma BW5147 have been isolated which can no longer express functional TCR alpha- and beta-chains. By generating hybridomas with these variant fusion lines, TCR of any normal T lymphocyte, including TCR-gamma/delta, can be studied at a clonal level, without interference of the BW5147-derived receptor chains. In this study one of the variants has been useful in identifying the reactivity to allogeneic MHC Ag of BW5147 itself.

PMID:
2778316
[Indexed for MEDLINE]
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