Format

Send to

Choose Destination
Angew Chem Int Ed Engl. 2016 Nov 14;55(47):14807-14811. doi: 10.1002/anie.201608937. Epub 2016 Oct 26.

(C6 F5 )3 B Catalyzed Chemoselective and ortho-Selective Substitution of Phenols with α-Aryl α-Diazoesters.

Author information

1
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
2
Department of Physics, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.

Abstract

The development of an efficient method for the site-selective substitution of unprotected phenols has long been considered as an attractive but challenging task. Herein, we describe a highly chemo- and ortho-selective substitution reaction of phenols with α-aryl α-diazoacetates with commercially available (C6 F5 )3 B as the catalyst. This reaction proceeds under simple and mild conditions with high efficiency, it features a wide substrate scope and can be easily scaled up.

KEYWORDS:

C−H functionalization; boron catalysis; chemoselectivity; diazo compounds; phenols

PMID:
27782348
DOI:
10.1002/anie.201608937

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center