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Chem Commun (Camb). 2016 Nov 3;52(90):13307-13310.

C8-H bond activation vs. C2-H bond activation: from naphthyl amines to lactams.

Author information

1
College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, P. R. China. aiwenlei@whu.edu.cn.
2
School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, P. R. China. lanyu@cqu.edu.cn.
3
College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, P. R. China. aiwenlei@whu.edu.cn and State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China.

Abstract

Pd-catalyzed selective amine-oriented C8-H bond functionalization/N-dealkylative carbonylation of naphthyl amines has been achieved. The amine group from dealkylation is proposed to be the directing group for promoting this process. It represents a straightforward and easy method to access various biologically important benzo[cd]indol-2(1H)-one derivatives.

PMID:
27782272
DOI:
10.1039/c6cc06358f

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