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Molecules. 2016 Oct 5;21(10). pii: E1326.

Saponins from Chinese Medicines as Anticancer Agents.

Author information

1
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. xuxiaohuang1125@gmail.com.
2
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. liting19890717@msn.cn.
3
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. vivfong530@gmail.com.
4
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. xiaojiachen@umac.mo.
5
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. ytwang@umac.mo.
6
College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China. hmq1115@126.com.
7
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. jinjianlu@umac.mo.

Abstract

Saponins are glycosides with triterpenoid or spirostane aglycones that demonstrate various pharmacological effects against mammalian diseases. To promote the research and development of anticancer agents from saponins, this review focuses on the anticancer properties of several typical naturally derived triterpenoid saponins (ginsenosides and saikosaponins) and steroid saponins (dioscin, polyphyllin, and timosaponin) isolated from Chinese medicines. These saponins exhibit in vitro and in vivo anticancer effects, such as anti-proliferation, anti-metastasis, anti-angiogenesis, anti-multidrug resistance, and autophagy regulation actions. In addition, related signaling pathways and target proteins involved in the anticancer effects of saponins are also summarized in this work.

KEYWORDS:

cancer; mechanism; steroid saponins; target; triterpenoid saponins

PMID:
27782048
PMCID:
PMC6272920
DOI:
10.3390/molecules21101326
[Indexed for MEDLINE]
Free PMC Article

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