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J Periodontal Res. 2017 Jun;52(3):574-581. doi: 10.1111/jre.12425. Epub 2016 Oct 26.

Gingival crevicular fluid tissue/blood vessel-type plasminogen activator and plasminogen activator inhibitor-2 levels in patients with rheumatoid arthritis: effects of nonsurgical periodontal therapy.

Author information

1
Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey.
2
Department of Periodontology, Faculty of Dentistry, Istanbul Medipol University, İstanbul, Turkey.
3
Department of Periodontology, Faculty of Dentistry, Süleyman Demirel University, Isparta, Turkey.
4
Department of Physical Medicine and Rehabilitation, Ankara Numune Training and Research Hospital, Ankara, Turkey.
5
Department of Periodontology, Faculty of Dentistry, Pamukkale University, Denizli, Turkey.
6
Department of Medical Biochemistry, School of Medicine, Acıbadem University, Ankara, Turkey.
7
Division of Periodontology, College of Dentistry, The Ohio State University, Columbus, OH, USA.

Abstract

BACKGROUND AND OBJECTIVE:

The aim of this study was to evaluate the effect of nonsurgical periodontal therapy on clinical parameters and gingival crevicular fluid levels of tissue/blood vessel-type plasminogen activator (t-PA) and plasminogen activator inhibitor-2 (PAI-2) in patients with periodontitis, with or without rheumatoid arthritis (RA).

MATERIAL AND METHODS:

Fifteen patients with RA and chronic periodontitis (RA-P), 15 systemically healthy patients with chronic periodontitis (H-P) and 15 periodontally and systemically healthy volunteers (C) were included in the study. Plaque index, gingival index, probing pocket depth, clinical attachment level, bleeding on probing, gingival crevicular fluid t-PA and PAI-2 levels, erythrocyte sedimentation rate, serum C-reactive protein and disease activity score were evaluated at baseline and 3 mo after mechanical nonsurgical periodontal therapy.

RESULTS:

All periodontal clinical parameters were significantly higher in the RA-P and H-P groups compared with the C group (p < 0.001) and decreased significantly after treatment (p < 0.001). Pretreatment t-PA levels were highest in the RA-P group and significantly decreased post-treatment (p = 0.047). Pre- and post-treatment PAI-2 levels were significantly lower in controls compared with both periodontitis groups (p < 0.05). Gingival crevicular fluid volume and the levels of t-PA and PAI-2 were significantly correlated.

CONCLUSION:

In patients with periodontitis and RA, nonsurgical periodontal therapy reduced the pretreatment gingival crevicular fluid t-PA levels, which were significantly correlated with gingival crevicular fluid PAI-2 levels. The significantly higher t-PA and PAI-2 gingival crevicular fluid levels in periodontal patients, regardless of systemic status, suggest that the plasminogen activating system plays a role in the disease process of periodontitis.

KEYWORDS:

gingival crevicular fluid; periodontitis; plasminogen activator inhibitor-2; rheumatoid arthritis; tissue plasminogen activator

PMID:
27781272
DOI:
10.1111/jre.12425
[Indexed for MEDLINE]

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