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J Virus Erad. 2016 Oct 5;2(4):243-250.

Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA.

Author information

1
Division of AIDS Research , National Institute of Mental Health, National Institutes of Health , Bethesda , MD , USA.
2
Department of Infectious Diseases , IRCCS San Raffaele Scientific Institute , Milan , Italy.
3
Department of HIV Medicine , Ruby Hall Clinic , Pune , India.
4
Department of Infectious Diseases , 'Dr Victor Babes' Hospital for Infectious and Tropical Diseases , Bucharest , Romania.
5
Department of Pharmacology and Experimental Neuroscience , University of Nebraska Medical Center , Omaha , NE , USA.
6
Department of Cancer Immunology and Virology , Dana-Farber Cancer Institute , Boston , MA , USA.
7
Department of Infectious Diseases , Sahlgrenska Academy , University of Gothenburg , Gothenburg , Sweden.
8
Department of Microbiology and Immunology , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA .
9
Department of Medicine , University of California , San Diego , CA , USA.
10
Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
11
Section of Infections of the Nervous System , National Institute of Neurological Diseases and Stroke , National Institutes of Health , Bethesda , MD , USA.
12
Department of Internal Medicine - HIV Unit , Hospital La Paz-IdiPAZ , Madrid , Spain .
13
Johns Hopkins University School of Medicine & Bloomberg School of Public Health , Baltimore , MD , USA.
14
Department of Neurology , University of California , San Francisco , CA , USA.
15
Department of Neurology , Johns Hopkins University , Baltimore , MD , USA.
16
Division of Infectious Diseases , Imperial College London , London , UK.
17
Division of Neurology , University of Puerto Rico-Medical Sciences Campus , San Juan , PR , USA.
18
Department of Infectious Diseases , Alfred Health , Melbourne , Australia.
19
Department of Neurology , Yale University , New Haven , CT , USA.

Abstract

CSF HIV escape is a recently recognised phenomenon that suggests that despite suppressive treatment, HIV RNA may be detected in the CNS compartment in some individuals. In rare cases this is associated with clinical neurological disease, while in most cases, neurological consequences are not apparent. Attempts at characterising the biological substrates of CSF escape and further investigating the neurological consequences need to be made to better understand the implications of this condition for the HIV cure agenda as well as for clinical outcomes. The Global CSF HIV-1 Escape Consortium meeting, convened by the US National Institute of Mental Health, was a first step to gather investigators from diverse sites to discuss opportunities for future collaborative work on this emerging issue. To better understand CSF HIV escape and allow cross-site data reconciliation, it will be useful to reach a consensus set of definitions of the distinct forms of CSF escape, without which concerted cross-site efforts are difficult.

PMID:
27781109
PMCID:
PMC5075354

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