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Oncotarget. 2016 Nov 22;7(47):77807-77814. doi: 10.18632/oncotarget.12799.

Somatostatin receptor based PET/CT in patients with the suspicion of cardiac sarcoidosis: an initial comparison to cardiac MRI.

Author information

1
Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
2
Department of Internal Medicine, University Hospital Würzburg, Würzburg, Germany.
3
Comprehensive Heart Failure Center, University Würzburg, Würzburg, Germany.
4
Department of Internal Medicine II - Pneumology/Cardiology, University Hospital Bonn, Bonn, Germany.
5
Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany.
6
Department of Radiology, University Hospital Bonn, Bonn, Germany.

Abstract

Diagnosis of cardiac sarcoidosis is often challenging. Whereas cardiac magnetic resonance imaging (CMR) and positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) are most commonly used to evaluate patients, PET/CT using radiolabeled somatostatin receptor (SSTR) ligands for visualization of inflammation might represent a more specific alternative. This study aimed to investigate the feasibility of SSTR-PET/CT for detecting cardiac sarcoidosis in comparison to CMR.15 patients (6 males, 9 females) with sarcoidosis and suspicion on cardiac involvement underwent SSTR-PET/CT imaging and CMR. Images were visually scored. The AHA 17-segment model of the left myocardium was used for localization and comparison of inflamed myocardium for both imaging modalities. In semi-quantitative analysis, mean (SUVmean) and maximum standardized uptake values (SUVmax) of affected myocardium were calculated and compared with both remote myocardium and left ventricular (LV) cavity.SSTR-PET was positive in 7/15, CMR in 10/15 patients. Of the 3 CMR+/PET- subjects, one patient with minor involvement (<25% of wall thickness in CMR) was missed by PET. The remaining two CMR+/PET- patients displayed no adverse cardiac events during follow-up.In the 17-segment model, PET/CT yielded 27 and CMR 29 positive segments. Overall concordance of the 2 modalities was 96.1% (245/255 segments analyzed). SUVmean and SUVmax in inflamed areas were 2.0±1.2 and 2.6±1.2, respectively. The lesion-to-remote myocardium and lesion-to-LV cavity ratios were 1.8±0.2 and 1.9±0.2 for SUVmean and 2.0±0.3 and 1.7±0.3 for SUVmax, respectively.Detection of cardiac sarcoidosis by SSTR-PET/CT is feasible. Our data warrant further analysis in larger prospective series.

KEYWORDS:

DOTATOC; PET; SSTR; sarcoidosis; somatostatin receptor

PMID:
27780922
PMCID:
PMC5363622
DOI:
10.18632/oncotarget.12799
[Indexed for MEDLINE]
Free PMC Article

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