The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition

Gareth Prosser; Julius Brandenburg; Norbert Reiling; Clifton Earl Barry 3rd; Robert J Wilkinson; Katalin A Wilkinson

doi:10.1016/j.micinf.2016.10.001

The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition

Microbes Infect. 2017 Mar;19(3):177-192. doi: 10.1016/j.micinf.2016.10.001. Epub 2016 Oct 22.

Authors

Gareth Prosser¹, Julius Brandenburg², Norbert Reiling³, Clifton Earl Barry 3rd⁴, Robert J Wilkinson⁵, Katalin A Wilkinson⁶

Affiliations

¹ Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, 20892, United States.
² Microbial Interface Biology, Priority Research Area Infections, Forschungszentrum Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 1-40, D-23845, Borstel, Germany.
³ Microbial Interface Biology, Priority Research Area Infections, Forschungszentrum Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 1-40, D-23845, Borstel, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck, Borstel, Germany.
⁴ Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, 20892, United States; Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa.
⁵ Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa; The Francis Crick Institute, London, NW1 2AT, United Kingdom; Department of Medicine, Imperial College, London, W2 1PG, United Kingdom. Electronic address: r.j.wilkinson@imperial.ac.uk.
⁶ Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa; The Francis Crick Institute, London, NW1 2AT, United Kingdom.

Abstract

Mycobacterium tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding pathogenesis and thereby to derive new drug treatments and vaccines.

Keywords: Antigens; Hypoxia; Lipid droplets; Macrophage; T cells; Tuberculosis.

Publication types

Review

MeSH terms

Animals
Disease Models, Animal
Humans
Hypoxia / pathology*
Macrophages / immunology*
Mycobacterium tuberculosis / immunology*
Mycobacterium tuberculosis / pathogenicity*
T-Lymphocytes / immunology*
Tuberculosis / immunology*
Tuberculosis / pathology*

Abstract

Publication types

MeSH terms

Grants and funding