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Clin Chim Acta. 2016 Dec 1;463:122-128. doi: 10.1016/j.cca.2016.10.026. Epub 2016 Oct 22.

High-sensitive cardiac troponin T (hs-cTnT) assay as serum biomarker to predict cardiac risk in myotonic dystrophy: A case-control study.

Author information

1
Research Laboratories, IRCCS Policlinico San Donato, San Donato Milanese, Italy; Service of Laboratory Medicine, IRCCS Policlinico San Donato, San Donato Milanese, Italy. Electronic address: rea.valaperta@grupposandonato.it.
2
Department of Public Health, Experimental and Forensic Medicine, Unit of Biostatistics and Clinical Epidemiology, Unit of Hygiene, University of Pavia, Italy.
3
Laboratory of Muscle Histopathology and Molecular Biology, IRCCS Policlinico San Donato, San Donato Milanese, Italy.
4
Research Laboratories, IRCCS Policlinico San Donato, San Donato Milanese, Italy; Service of Laboratory Medicine, IRCCS Policlinico San Donato, San Donato Milanese, Italy.
5
Service of Laboratory Medicine, IRCCS Policlinico San Donato, San Donato Milanese, Italy.
6
Clinical Cardiology Unit and CCU, IRCCS Policlinico San Donato, San Donato Milanese, Italy.
7
Department of Biomedical Sciences for Health, University of Milan, IRCCS Policlinico San Donato, San Donato Milanese, Italy.
8
Laboratory of Stem Cells for Tissue Engineering, IRCCS Policlinico San Donato, San Donato Milanese, Italy.
9
Laboratory of Muscle Histopathology and Molecular Biology, IRCCS Policlinico San Donato, San Donato Milanese, Italy; Department of Biomedical Sciences for Health, University of Milan, IRCCS Policlinico San Donato, San Donato Milanese, Italy.

Abstract

BACKGROUND:

Myotonic dystrophy (DM) is a genetic disorder caused by nucleotide repeats expansion. Sudden death represents the main cause of mortality in DM patients. Here, we investigated the relationship between serum cardiac biomarkers with clinical parameters in DM patients.

METHODS:

Case-control study included 59 DM patients and 22 healthy controls. An additional group of 62 controls with similar cardiac defects to DM were enrolled.

RESULTS:

NT-proBNP, hs-cTnT and CK levels were significantly increased in DM patients compared to healthy subjects (p=0.0008, p<0.0001, p<0.0001). Also, hs-cTnT levels were significantly higher in DM compared to control group with cardiac defects (p=0.0003). Positive correlation was found between hs-cTnT and hs-cTnI in both DM patients and controls (p=0.019, p=0.002). Independently from the age, the risk of DM disease was positively related to an increase in hs-cTnT (p=0.03). On the contrary, the risk of DM was not related to hs-cTnI, but was evidenced a role of PR interval (p=0.03) and CK (p=0.08).

CONCLUSIONS:

The levels of hs-cTnT were significantly higher in DM patients. Analysis, with anti-cTnT, shows that this increase might be linked to heart problems. This last finding suggests that hs-cTnT might represent a helpful serum biomarker to "predict" cardiac risk in DM disease.

KEYWORDS:

Cardiac involvement; Myotonic dystrophy; hs-cTnI; hs-cTnT

PMID:
27780717
DOI:
10.1016/j.cca.2016.10.026
[Indexed for MEDLINE]

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