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J Enzyme Inhib Med Chem. 2017 Dec;32(1):78-83. doi: 10.1080/14756366.2016.1235568. Epub 2016 Oct 25.

Tyrosinase inhibitory components from Aloe vera and their antiviral activity.

Author information

1
a Department of Horticultural and Crop Environment , National Institute of Horticultural and Herbal Science, RDA , Wanju , Republic of Korea.
2
b College of Pharmacy, Chungnam National University , Daejeon , Republic of Korea.

Abstract

A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2-9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC50 value of 9.8 ± 0.9 µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.

KEYWORDS:

Aloe vera; Pepper mild mottle virus; Xanthorrhoeaceae; molecular docking; tyrosinase

PMID:
27778516
DOI:
10.1080/14756366.2016.1235568
[Indexed for MEDLINE]

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