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Evid Based Complement Alternat Med. 2016;2016:3606820. Epub 2016 Sep 29.

Acmella oleracea and Achyrocline satureioides as Sources of Natural Products in Topical Wound Care.

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Chemical, Biological and Agricultural Research Center (CPQBA), University of Campinas, Campinas, SP, Brazil.
Biology Institute, Department of Biochemistry and Tissue Biology, University of Campinas, Campinas, SP, Brazil.
Institute of Biosciences, Department of Biology, Sao Paulo State University, Rio Claro, SP, Brazil.


The Brazilian forests have one of the world's biggest biodiversities. Achyrocline satureioides (macela) and Acmella oleracea (jambu) are native species from Brazil with a huge therapeutic potential, with proved anti-inflammatory and anesthetic action, respectively. The jambu's crude extract after depigmentation with activated charcoal and macela's essential oil were incorporated in a film made with hydroxyethyl cellulose. Those films were evaluated by mechanical test using a texturometer and anti-inflammatory and anesthetic activities by in vivo tests: wound healing and antinociceptive. The film containing the highest concentration of depigmented jambu's extract and macela's essential oil obtained an anesthesia time of 83.6 (±28.5) min longer when compared with the positive control EMLA®; the same occurred with the wound healing test; the film containing the highest concentration had a higher wound contraction (62.0% ± 12.1) compared to the positive control allantoin and the histopathological analysis demonstrated that it increases collagen synthesis and epidermal thickening. The results demonstrate that the films have a potential use in skin wounds, pressure sore, and infected surgical wounds treatment.

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