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J Biol Chem. 1989 Sep 25;264(27):16160-4.

Stimulation of the human heat shock protein 70 promoter in vitro by simian virus 40 large T antigen.

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Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.


Simian virus 40 large tumor (T) antigen stimulates transcription from the SV40 late promoter and some cellular genes. We report here the novel finding that purified T antigen preferentially stimulates transcription from the human heat shock protein 70 promoter in an in vitro transcription system. T antigen is thus capable of stimulating transcription by a process that does not require synthesis of other proteins and that may involve a direct interaction with preexisting cellular factors.

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