Format

Send to

Choose Destination
Life Sci. 2016 Dec 15;167:32-38. doi: 10.1016/j.lfs.2016.10.023. Epub 2016 Oct 22.

Longevity study with low doses of selegiline/(-)-deprenyl and (2R)-1-(1-benzofuran-2-yl)-N-propylpentane-2-amine (BPAP).

Author information

1
Semmelweis University, Department of Pharmacology and Pharmacotherapy, Budapest, Hungary. Electronic address: knoll.jozsef@med.semmelweis-univ.hu.
2
Semmelweis University, Department of Pharmacology and Pharmacotherapy, Budapest, Hungary.

Abstract

AIMS:

The first longevity study demonstrating that rats treated with the MAO-B inhibitory dose of (-)-deprenyl (0.25mg/kg) lived significantly longer than their saline-treated peers was published in 1988, and corroborated in many papers. The recent findings that (-)-deprenyl is primarily a PEA-derived synthetic catecholaminergic activity enhancer substance; (2R)-1-(1-benzofuran-2-yl)-N-propylpentane-2-amine (BPAP) is a tryptamine-derived synthetic enhancer substance, initiated our first longevity study on rats with low enhancer doses of (-)-deprenyl and BPAP to test the enhancer effect's role in life extension.

MAIN METHODS:

We used the shuttle box technique for selecting the optimum doses of (-)-deprenyl and BPAP. (-)-Deprenyl exerts in rats in 0.001mg/kg its 'specific' enhancer effect and in 0.1mg/kg its 'non-specific' enhancer effect. BPAP exerts its 'specific' enhancer effect in 0.0001mg/kg and its 'non-specific' enhancer effect in 0.05mg/kg. Groups of male Wistar rats (N=40) were treated subcutaneously from their 10th week until death, three times weekly, with saline (0.5ml/kg), and the selected doses of (-)-deprenyl or BPAP, respectively. As an indicator of aging we tested the age-related changes in their learning ability.

KEY FINDINGS:

Rats treated with 0.0001 or 0.05mg/kg BPAP lived significantly longer than their saline treated peers (P<0.02) and BPAP was more potent in extending rats' lifespan than (-)-deprenyl. 18-month-old rats treated with 0.0001mg/kg BPAP were as good learners as 3-month-old saline treated rats.

SIGNIFICANCE:

The study revealed that the enhancer effect is responsible for life extension.

KEYWORDS:

(2R)-1-(1-benzofuran-2-yl)-N-propylpentane-2-amine (BPAP); Aging; Enhancer substances; Lifespan; Longevity study; Low dose treatment; Selegiline/(−)-deprenyl

PMID:
27777099
DOI:
10.1016/j.lfs.2016.10.023
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center