Lutein, a carotenoid, suppresses osteoclastic bone resorption and stimulates bone formation in cultures

Biosci Biotechnol Biochem. 2017 Feb;81(2):302-306. doi: 10.1080/09168451.2016.1243983. Epub 2016 Oct 25.

Abstract

Lutein, a member of the xanthophyll family of carotenoids, suppressed IL-1-induced osteoclast differentiation and bone resorption. The survival of mature osteoclasts was also suppressed by lutein in cultures. When lutein was added to the cultures of osteoblasts, lutein enhanced the formation of mineralized bone nodules by elevating BMP2 expression and inhibiting sclerostin expression. Lutein may be beneficial for bone health.

Keywords: bone formation; bone resorption; xanthophyll family of carotenoids.

MeSH terms

  • Animals
  • Bone Morphogenetic Protein 2 / metabolism
  • Bone Resorption / drug therapy*
  • Cells, Cultured
  • Gene Expression Regulation / drug effects
  • Lutein / pharmacology*
  • Lutein / therapeutic use
  • Mice
  • Osteoclasts / cytology
  • Osteoclasts / drug effects*
  • Osteoclasts / metabolism
  • Osteoclasts / pathology
  • Osteogenesis / drug effects*

Substances

  • Bmp2 protein, mouse
  • Bone Morphogenetic Protein 2
  • Lutein