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Expert Opin Drug Deliv. 2017 Aug;14(8):959-972. doi: 10.1080/17425247.2017.1252329. Epub 2016 Nov 10.

Inhaled phage therapy: a promising and challenging approach to treat bacterial respiratory infections.

Author information

1
a Université François Rabelais, UMR 1100 , Tours , France.
2
b INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100 , Tours , France.
3
c CHRU de Tours, Service de Pharmacie , Tours , France.
4
d Pherecydes Pharma , Romainville , France.
5
e CHRU de Tours, Service de Réanimation Polyvalente , Tours , France.
6
f DTF-Aerodrug , St Etienne , France.

Abstract

Bacterial respiratory tract infections (RTIs) are increasingly difficult to treat due to evolving antibiotic resistance. In this context, bacteriophages (or phages) are part of the foreseen alternatives or combination therapies. Delivering phages through the airways seems more relevant to accumulate these natural antibacterial viruses in proximity to their bacterial host, within the infectious site. Areas covered: This review addresses the potential of phage therapy to treat RTIs and discusses preclinical and clinical results of phages administration in this context. Recent phage formulation and aerosolization attempts are also reviewed, raising technical challenges to achieve efficient pulmonary deposition via inhalation. Expert opinion: Overall, the inhalation of phages as antibacterial treatment seems both clinically relevant and technically feasible. Several crucial points still need to be investigated, such as phage product pharmacokinetics and immunogenicity. Furthermore, given phage-specific features, appropriate regulatory and manufacturing guidelines will need to be defined. Finally, randomized controlled clinical trials should be carried out to establish phage therapy's clinical positioning in the antimicrobial arsenal against RTIs.

KEYWORDS:

Respiratory tract infection; aerosol delivery; antibiotic resistance; bacteriophage; biotherapeutics; formulation; phage therapy

PMID:
27776446
DOI:
10.1080/17425247.2017.1252329
[Indexed for MEDLINE]

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