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Gastroenterology. 2017 Jan;152(1):36-52. doi: 10.1053/j.gastro.2016.10.015. Epub 2016 Oct 20.

Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer.

Author information

1
University of Illinois at Chicago, Chicago, Illinois. Electronic address: bjung@uic.edu.
2
University of Illinois at Chicago, Chicago, Illinois.
3
Vanderbilt University, Nashville, Tennessee.

Abstract

Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. A high percentage of colorectal tumors contain mutations that disrupt TGF-β family member signaling. We review how TGF-β family member signaling is altered during development of colorectal cancer, models of study, interaction of pathways, and potential therapeutic strategies.

KEYWORDS:

Activin; Colon Cancer; Transforming Growth Factor β

PMID:
27773809
PMCID:
PMC5550896
DOI:
10.1053/j.gastro.2016.10.015
[Indexed for MEDLINE]
Free PMC Article

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