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Fertil Steril. 2016 Dec;106(7):1751-1756. doi: 10.1016/j.fertnstert.2016.09.009. Epub 2016 Oct 20.

Fertility treatment and childhood type 1 diabetes mellitus: a nationwide cohort study of 565,116 live births.

Author information

1
Perinatal Epidemiology Research Unit and Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark. Electronic address: laura@kettner.nu.
2
Perinatal Epidemiology Research Unit and Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.
3
Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.
4
Fertility Clinic, Department of Obstetrics and Gynecology, Herlev University Hospital, Herlev, Denmark.
5
Fertility Clinic, Department of Obstetrics and Gynecology, Aarhus University, Regional Hospital Horsens, Horsens, Denmark.

Abstract

OBJECTIVE:

To investigate the association between specific types of fertility treatment and childhood type 1 diabetes mellitus.

DESIGN:

Nationwide birth cohort study.

SETTING:

Not applicable.

PATIENT(S):

All pregnancies resulting in a live-born singleton child in Denmark from 1995 to 2003.

INTERVENTION(S):

Not applicable.

MAIN OUTCOME MEASURE(S):

Childhood type 1 diabetes mellitus identified from redeemed prescriptions for insulin until 2013.

RESULT(S):

The study included 565,116 singleton pregnancies. A total of 14,985 children were conceived by ovulation induction or intrauterine insemination, and 8,490 children were conceived by in vitro fertilization or intracytoplasmic sperm injection. During the follow-up period, 2,011 (0.4%) children developed type 1 diabetes mellitus. The primary analyses showed no association between fertility treatment and childhood type 1 diabetes mellitus. In secondary analyses, ovulation induction or intrauterine insemination with follicle-stimulating hormone was associated with an increased risk of type 1 diabetes mellitus (hazard ratio 3.22; 95% confidence interval 1.20 to 8.64). No clear associations were seen with other types of fertility treatment or with specific treatment indications.

CONCLUSION(S):

No association between fertility treatment and childhood type 1 diabetes mellitus was found. Ovulation induction or intrauterine insemination with follicle-stimulating hormone may be associated with an increased risk of childhood type 1 diabetes mellitus. However, this finding may be due to chance or to confounding by indication and thus requires further investigation.

KEYWORDS:

Assisted reproductive technology; intracytoplasmic sperm injection; intrauterine insemination; in vitro fertilization; ovulation induction; type 1 diabetes mellitus

[Indexed for MEDLINE]

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