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Indian Heart J. 2016 Sep - Oct;68(5):720-723. doi: 10.1016/j.ihj.2016.08.013. Epub 2016 Sep 10.

Diuretics in primary hypertension - Reloaded.

Author information

1
Cardiology, AIIMS, New Delhi, India. Electronic address: drsundeepmishra@hotmail.com.

Abstract

Diuretics have long been cherished as drugs of choice for uncomplicated primary hypertension. Robust mortality and morbidity data is available for diuretics to back this strategy. Off-late the interest for diuretics has waned off perhaps due to availability of more effective drugs but more likely due to perceived lack of tolerance and side-effect profile of high-dose of diuretics required for mortality benefit. Low-dose diuretics particularly thiazide diuretics are safer but lack the mortality benefit shown by high-dose. However, indapamide and low dose chlorthalidone have fewer side-effects but continue to provide mortality benefit.

KEYWORDS:

Cardiovascular outcome; Chlorthalidone; Diuretics; Hydrochlorothiazide; Indapamide; Mortality

PMID:
27773415
PMCID:
PMC5079206
DOI:
10.1016/j.ihj.2016.08.013
[Indexed for MEDLINE]
Free PMC Article

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