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Adv Exp Med Biol. 2016;929:247-267.

Anethole and Its Role in Chronic Diseases.

Author information

1
Department of Pharmacognosy, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa", Iasi, Romania. anaclara70@yahoo.com.
2
Department of Internal Medicine, Faculty of Medicine, "Sf. Spiridon" University Hospital Iasi, University of Medicine and Pharmacy "Grigore T. Popa", Iasi, Romania.
3
Department of Pharmacognosy, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa", Iasi, Romania.

Abstract

Anethole is the main fragrance and bioactive compound of anise, fennel, and star anise spices and more than other 20 plant species. It is widely used as flavor agent in food industry and other industries, in cosmetics, perfumery, and pharmaceuticals. In the last few years, various studies have revealed multiple beneficial effects of anethole for human health, such as anti-inflammatory, anticarcinogenic and chemopreventive, antidiabetic, immunomodulatory, neuroprotective, or antithrombotic, that are mediated by the modulation of several cell signaling pathways, mainly NF-kB and TNF-α signaling, and various ion channels. This chapter aims to review the scientific data and attempts to provide an insight into pharmacological activity of anethole and its therapeutic potential in human chronic diseases.

KEYWORDS:

AP-1 signaling pathways; Anethole; Anti-inflammatory; Anticarcinogenic; MAPK; NF-kB; STAT; TNF-α

PMID:
27771928
DOI:
10.1007/978-3-319-41342-6_11
[Indexed for MEDLINE]

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