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Mater Sci Eng C Mater Biol Appl. 2017 Jan 1;70(Pt 1):870-888. doi: 10.1016/j.msec.2016.09.069. Epub 2016 Sep 30.

Resorbable bone fixation alloys, forming, and post-fabrication treatments.

Author information

1
Dept. of Mechanical Industrial and Manufacturing Engineering, University of Toledo, Toledo, OH 43606, USA. Electronic address: Hamdy.e.ibrahim@gmail.com.
2
Dept. of Mechanical Industrial and Manufacturing Engineering, University of Toledo, Toledo, OH 43606, USA. Electronic address: nasr.sajedeh90@gmail.com.
3
Yazaki Technical Center America Inc., 3401 Calle Tecate, Camarillo, CA 93012, USA. Electronic address: behrang.poorganji@gmail.com.
4
Dept. of Plastic Surgery, The Ohio State University, Columbus, OH 43212, USA. Electronic address: David.Dean@osumc.edu.
5
Dept. of Mechanical Industrial and Manufacturing Engineering, University of Toledo, Toledo, OH 43606, USA. Electronic address: mohammad.elahinia@utoledo.edu.

Abstract

Metallic alloys have been introduced as biodegradable metals for various biomedical applications over the last decade owing to their gradual corrosion in the body, biocompatibility and superior strength compared to biodegradable polymers. Mg alloys possess advantageous properties that make them the most extensively studied biodegradable metallic material for orthopedic applications such as their low density, modulus of elasticity, close to that of the bone, and resorbability. Early resorption (i.e., <3months) and relatively inadequate strength are the main challenges that hinder the use of Mg alloys for bone fixation applications. The development of resorbable Mg-based bone fixation hardware with superior mechanical and corrosion performance requires a thorough understanding of the physical and mechanical properties of Mg alloys. This paper discusses the characteristics of successful Mg-based skeletal fixation hardware and the possible ways to improve its properties using different methods such as mechanical and heat treatment processes. We also review the most recent work pertaining to Mg alloys and surface coatings. To this end, this paper covers (i) the properties and development of Mg alloys and coatings with an emphasis on the Mg-Zn-Ca-based alloys; (ii) Mg alloys fabrication techniques; and (iii) strategies towards achieving Mg-based, resorbable, skeletal fixation devices.

KEYWORDS:

Additive manufacturing; Biodegradable metals; Bone fixation hardware; Corrosion; Heat treatment; Magnesium alloys

PMID:
27770965
DOI:
10.1016/j.msec.2016.09.069
[Indexed for MEDLINE]

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