Co-ordinated expression of the components of iron transport (mycobactin, exochelin and envelope proteins) in Mycobacterium neoaurum

FEMS Microbiol Lett. 1989 Jul 15;51(1):183-5. doi: 10.1016/0378-1097(89)90505-3.

Abstract

Mycobacterium neoaurum was grown with a range of iron concentrations from 0.01 to 4.0 micrograms/ml. Synthesis of the extracellular siderophore, exochelin, the intracellular iron storage compound, mycobactin and the iron-repressible envelope proteins were co-ordinately expressed. All three components of the iron transport system were synthesized when low amounts of iron (0.01 to 0.2 micrograms/ml) were added to the medium and were repressed when the iron concentration was increased to 0.5 micrograms/ml and above. These results re-inforce the conclusion that the iron-regulated proteins do fulfil an essential function in iron metabolism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / biosynthesis*
  • Iron / metabolism*
  • Iron Chelating Agents / biosynthesis*
  • Mycobacterium / metabolism*
  • Oxazoles / biosynthesis*
  • Peptides, Cyclic / biosynthesis*

Substances

  • Bacterial Proteins
  • Iron Chelating Agents
  • Oxazoles
  • Peptides, Cyclic
  • exochelins
  • mycobactins
  • Iron