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Magn Reson Med. 2016 Oct 21. doi: 10.1002/mrm.26480. [Epub ahead of print]

Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses.

Author information

  • 1Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
  • 2UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA.
  • 3Electrical Engineering, Stanford University, Stanford, California, USA.
  • 4HeartVista, Menlo Park, California, USA.
  • 5Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA. dan.vigneron@ucsf.edu.
  • 6UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA. dan.vigneron@ucsf.edu.

Abstract

PURPOSE:

Balanced steady-state free precession (bSSFP) sequences can provide superior signal-to-noise ratio efficiency for hyperpolarized (HP) carbon-13 (13 C) magnetic resonance imaging by efficiently utilizing the nonrecoverable magnetization, but managing their spectral response is challenging in the context of metabolic imaging. A new spectrally selective bSSFP sequence was developed for fast imaging of multiple HP 13 C metabolites with high spatiotemporal resolution.

THEORY AND METHODS:

This novel approach for bSSFP spectral selectivity incorporates optimized short-duration spectrally selective radiofrequency pulses within a bSSFP pulse train and a carefully chosen repetition time to avoid banding artifacts.

RESULTS:

The sequence enabled subsecond 3D dynamic spectrally selective imaging of 13 C metabolites of copolarized [1-13 C]pyruvate and [13 C]urea at 2-mm isotropic resolution, with excellent spectral selectivity (∼100:1). The sequence was successfully tested in phantom studies and in vivo studies with normal mice.

CONCLUSION:

This sequence is expected to benefit applications requiring dynamic volumetric imaging of metabolically active 13 C compounds at high spatiotemporal resolution, including preclinical studies at high field and, potentially, clinical studies.Magn Reson Med, 2016. © 2016 International Society for Magnetic Resonance in Medicine.

KEYWORDS:

balanced SSFP; banding artifact; hyperpolarized C-13; optimized RF pulse design; spectrally selective

PMID:
27770458
DOI:
10.1002/mrm.26480
[PubMed - as supplied by publisher]
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