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Acta Neuropathol. 2017 Jan;133(1):139-147. doi: 10.1007/s00401-016-1629-y. Epub 2016 Oct 21.

Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis.

Author information

  • 1Division of Infection and Immunity, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK. sofia.morfopoulou.10@ucl.ac.uk.
  • 2Virology Division, National Institute for Biological Standards and Control, Potters Bar, EN6 3QG, UK.
  • 3Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.
  • 4Department of Immunology, Great Ormond Street Hospital, NHS Foundation Trust, London, WC1N 3JH, UK.
  • 5Department of Radiology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.
  • 6Department of Microbiology, Boston University School of Medicine, Boston, MA, 02118, USA.
  • 7Genetics and Genomics Medicine UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.
  • 8Department of Histopathology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.
  • 9Neurosciences Department, Great Ormond Street Hospital, NHS Foundation Trust, London, WC1N 3JH, UK.
  • 10Molecular Pathology Programme, Centre for Cancer Research and Cell Biology, Queen's University, Belfast, UK.
  • 11Tissue Pathology, Belfast Health and Social Care Trust, Belfast City Hospital, Lisburn Road, Belfast, UK.
  • 12Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham, NG7 2UH, UK.
  • 13UCL Genetics Institute, University College London, London, WC1E 6BT, UK.
  • 14Division of Infection and Immunity, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK.
  • 15Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.
  • 16Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.
  • 17Great Ormond Street Hospital for Children, NHS Foundation Trust, Molecular and Cellular Immunology, London, WC1N 3JH, UK.
  • 18UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.

Abstract

Routine childhood vaccination against measles, mumps and rubella has virtually abolished virus-related morbidity and mortality. Notwithstanding this, we describe here devastating neurological complications associated with the detection of live-attenuated mumps virus Jeryl Lynn (MuVJL5) in the brain of a child who had undergone successful allogeneic transplantation for severe combined immunodeficiency (SCID). This is the first confirmed report of MuVJL5 associated with chronic encephalitis and highlights the need to exclude immunodeficient individuals from immunisation with live-attenuated vaccines. The diagnosis was only possible by deep sequencing of the brain biopsy. Sequence comparison of the vaccine batch to the MuVJL5 isolated from brain identified biased hypermutation, particularly in the matrix gene, similar to those found in measles from cases of SSPE. The findings provide unique insights into the pathogenesis of paramyxovirus brain infections.

PMID:
27770235
PMCID:
PMC5209397
DOI:
10.1007/s00401-016-1629-y
[PubMed - in process]
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