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J Alzheimers Dis. 2017;55(3):893-897.

Aortic Valve Calcification and the Risk of dementia: A Population-Based Study.

Author information

1
Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
2
Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.
3
Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.
4
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA.

Abstract

The association of aortic valve calcification (AVC) with dementia remains unknown. In 2,428 non-demented participants from the population-based Rotterdam Study, we investigated the association of CT-assessed AVC with risk of dementia and cognitive decline. AVC was present in 33.1% of the population. During a median follow-up of 9.3 years, 160 participants developed dementia. We found no association between presence of AVC and risk of all-cause dementia [hazard ratio (HR): 0.89 (95% confidence interval (CI):0.63;1.26)]. Presence of AVC was not associated with cognitive decline on any of the cognitive tests, nor with a measure of global cognition.

KEYWORDS:

Aortic valve pathology; calcification; dementia; epidemiology; imaging

PMID:
27767996
DOI:
10.3233/JAD-160871
[Indexed for MEDLINE]

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