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Ren Fail. 2017 Nov;39(1):7-12. doi: 10.1080/0886022X.2016.1244071. Epub 2016 Oct 21.

Urinary l-type fatty acid-binding protein is a predictor of early renal function after partial nephrectomy.

Author information

1
a Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.

Abstract

PURPOSE:

Urinary biomarkers of renal injury urinary may identify loss of renal function following nephron-sparing surgery (NSS). This study was designed to evaluate whether urinary l-type fatty acid-binding protein (l-FABP) is an early biomarker of loss of renal function after NSS. Specifically, the kinetics of urinary l-FABP level after NSS and its correlation with factors related to ischemic renal injury were analyzed.

METHODS:

This study prospectively evaluated 18 patients who underwent NSS between July and December 2014, including 12 who underwent laparoscopic and six who underwent robot-assisted partial nephrectomy. Urinary l-FABP concentrations were measured preoperatively and 1, 2, 3, 6, 12, 24, 48, and 72 h after renal artery declamping. Loss of renal function loss was calculated by comparing the effective renal plasma flow, as determined by 99mTc-mercaptoacetyltriglycine (MAG3) clearance, on the operated and normal sides. The decrease in estimated glomerular filtration rate from before surgery to six months after surgery was also measured.

RESULTS:

Urinary l-FABP concentration peaked within 2 h of declamping, which may quantify nephron damage caused by ischemia. The decrease in MAG3 reduction ratio correlated with both the ischemia time and peak urinary l-FABP concentration. Peak urinary l-FABP concentration showed a significant correlation with MAG3 reduction ratio.

CONCLUSIONS:

l-FABP is a suitable urinary biomarker for predicting the extent of ischemic renal injury.

KEYWORDS:

l-Type fatty acid-binding protein; partial nephrectomy; renal function; renal injury; urinary biomarker

PMID:
27767358
PMCID:
PMC6014395
DOI:
10.1080/0886022X.2016.1244071
[Indexed for MEDLINE]
Free PMC Article

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