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Electrophoresis. 1989 Jul;10(7):489-93.

Elevated plasma levels of haptoglobin in Duchenne muscular dystrophy:electrophoretic variants in patients with a severe form of the disease.

Author information

1
Department of Genetics, University of Edinburgh, Scotland.

Abstract

Analysis of plasma proteins of Duchenne muscular dystrophy (DMD) patients and normal age-matched boys using two dimensional gel electrophoresis and densitometry indicated a three-fold increase in the average haptoglobin level in DMD plasma. Two electrophoretic variants of haptoglobin in which the alpha 2 chain had more basic or more acidic spots were found in DMD patients with a rapidly progressing form of the disease. The basic variant was present in relatively low amount. Possible reasons for the elevated haptoglobin levels are discussed.

PMID:
2776732
DOI:
10.1002/elps.1150100707
[Indexed for MEDLINE]

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