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J Enzyme Inhib Med Chem. 2017 Dec;32(1):130-136. doi: 10.1080/14756366.2016.1238366. Epub 2016 Oct 21.

Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase.

Author information

1
a Department of Life and Environmental Sciences , University of Cagliari , Cagliari , Italy.
2
b Department of Life and Environmental Sciences , University of Cagliari, Cittadella Universitaria di Monserrato , Cagliari , Italy.

Abstract

A series of 3-3-{2-[2-3-methyl-4-phenyl-2,3-dihydro-1,3-thiazol-2-ylidene]hydrazin-1-ylidene-2,3-dihydro-1H-indol-2-one derivatives has been designed and synthesized to study their activity on both HIV-1 (Human Immunodeficiency Virus type 1) RT (Reverse Transcriptase) associated functions. These derivatives are analogs of previously reported series whose biological activity and mode of action have been investigated. In this work we investigated the influence of the introduction of a methyl group in the position 3 of the dihydrothiazole ring and of a chlorine atom in the position 5 of the isatin nucleus. The new synthesized compounds are active towards both DNA polymerase and ribonuclease H in the µM range. The nature of the aromatic group in the position 4 of the thiazole was relevant in determining the biological activity.

KEYWORDS:

HIV-1 therapeutic agents; Isatin derivatives; RT dual inhibitors

PMID:
27766892
PMCID:
PMC6010014
DOI:
10.1080/14756366.2016.1238366
[Indexed for MEDLINE]
Free PMC Article

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