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Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):35-42. doi: 10.1161/ATVBAHA.116.308198. Epub 2016 Oct 20.

Monocyte Conversion During Inflammation and Injury.

Author information

1
From the Department of Microbiology, Immunology, and Infectious Diseases (R.M.K., P.K.) and Department of Physiology and Pharmacology (P.K., J.F.D.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Canada.

Abstract

Monocytes are circulating leukocytes important in both innate and adaptive immunity, primarily functioning in immune defense, inflammation, and tissue remodeling. There are 2 subsets of monocytes in mice (3 subsets in humans) that are mobilized from the bone marrow and recruited to sites of inflammation, where they carry out their respective functions in promoting inflammation or facilitating tissue repair. Our understanding of the fate of these monocyte subsets at the site of inflammation is constantly evolving. This brief review highlights the plasticity of monocyte subsets and their conversion during inflammation and injury.

KEYWORDS:

infection; inflammation; innate immunity; macrophages; monocytes

PMID:
27765768
DOI:
10.1161/ATVBAHA.116.308198
[Indexed for MEDLINE]

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