Format

Send to

Choose Destination
Toxicology. 2016 Nov 30;372:12-21. doi: 10.1016/j.tox.2016.10.010. Epub 2016 Oct 17.

Acephate exposure during a perinatal life program to type 2 diabetes.

Author information

1
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil. Electronic address: tatianeribeiro2@hotmail.com.
2
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil.
3
Institute of Health Sciences, Federal University of Mato Grosso, 78.557-267 Sinop, MT, Brazil.
4
Laboratory of Molecular Endocrinology, Carlos Chagas Filho Biophysis Institute, Federal University of Rio de Janeiro, 21.941-902 Rio de Janeiro, RJ, Brazil.
5
Laboratory of Neuroscience and Cardiovascular Physiology, Department of Physiological Sciences, Federal University of Goiás, 74690-900 Goiânia, GO, Brazil.
6
Molecular Signalling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 20892 Bethesda, MD, USA.
7
Univ. Lille, CNRS, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France.
8
Department of Biochemistry and Biomedical Sciences, Ob/Gyn, and Pediatrics MacMaster University-8S 4L8, Hamilton, Ontario, Canada.
9
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil; UPSP-EGEAL Institut Polytechnique LaSalle de Beauvais, BP, 30313-60026 Beauvais Cedex, France.

Abstract

Acephate has been used extensively as an insecticide in agriculture. Its downstream sequelae are associated with hyperglycemia, lipid metabolism dysfunction, DNA damage, and cancer, which are rapidly growing epidemics and which lead to increased morbidity and mortality rates and soaring health-care costs. Developing interventions will require a comprehensive understanding of which excess insecticides during perinatal life can cause insulin resistance and type 2 diabetes. A Wistar rat animal model suggests that acephate exposure during pregnancy and lactation causes alterations in maternal glucose metabolism and programs the offspring to be susceptible to type 2 diabetes at adulthood. Therapeutic approaches based on preventive actions to food contaminated with insecticides during pregnancy and lactation could prevent new cases of type 2 diabetes.

KEYWORDS:

Acephate; Glucose metabolism; Lactation; Lipid metabolism; Offspring; Pregnancy

PMID:
27765684
DOI:
10.1016/j.tox.2016.10.010
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center