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Trends Cell Biol. 2017 Feb;27(2):110-125. doi: 10.1016/j.tcb.2016.09.010. Epub 2016 Oct 17.

Microtubule Motors Drive Hedgehog Signaling in Primary Cilia.

Author information

1
Department of Physiology and Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
2
Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Biochemistry, Cell, and Molecular Biology Program, Weill Graduate School of Medical Sciences of Cornell University, 1300 York Avenue, New York, NY 10065, USA.
3
Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address: k-anderson@ski.mskcc.org.

Abstract

The mammalian Hedgehog (Hh) signaling pathway is required for development and for maintenance of adult stem cells, and overactivation of the pathway can cause tumorigenesis. All responses to Hh family ligands in mammals require the primary cilium, an ancient microtubule-based organelle that extends from the cell surface. Genetic studies in mice and humans have defined specific functions for cilium-associated microtubule motor proteins: they act in the construction and disassembly of the primary cilium, they control ciliary length and stability, and some have direct roles in mammalian Hh signal transduction. These studies highlight how integrated genetic and cell biological studies can define the molecular mechanisms that underlie cilium-associated health and disease.

KEYWORDS:

Hedgehog pathway; ciliopathies; dynein; kinesin; microtubules; primary cilia

PMID:
27765513
PMCID:
PMC5258846
DOI:
10.1016/j.tcb.2016.09.010
[Indexed for MEDLINE]
Free PMC Article

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