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Oncotarget. 2016 Nov 15;7(46):76151-76158. doi: 10.18632/oncotarget.12691.

Expression of CK19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue.

Author information

1
Department of Cranio-, Maxillofacial and Oral Surgery, University Hospital Zurich, Zürich, Switzerland.
2
Department of Pathology, University Hospital Zurich, Zürich, Switzerland.
3
Department of Otorhinolaryngology, University Hospital Zurich, Zürich, Switzerland.
4
Department of Radiation Oncology, University Hospital Zurich, Zürich, Switzerland.
5
Department of Oncology, University Hospital Zurich, Zürich, Switzerland.
6
Department of Pathology, Cantonal Hospital Chur, Chur, Switzerland.
7
Cancer Registry Zurich and Zug, University Hospital Zurich, Zürich, Switzerland.

Abstract

OBJECTIVES:

To explore the prognostic role of CK19 expression in squamous cell carcinomas within a well-defined cohort of oral tongue cancer patients.

METHODS:

In our retrospective study, we investigated 129 patients with tongue cancer that had suitable material for inclusion in a tissue microarray (TMA). Where possible, samples were taken from central and peripheral regions of the tumor to generate a representative sample of the tumor. The expression level of CK19 was assessed by immunohistochemical staining.

RESULTS:

Expression of CK19 in squamous cell carcinoma of the tongue was identified as a negative predictor for overall survival (OS; p<0.000) and disease specific survival (DSS; p=0.001). No significant difference could be shown for disease free survival (DFS) between patients with positive and negative CK19 staining (p=.094).

CONCLUSION:

This is the first description of the highly significant role of CK19 in a selective, organ specific head and neck cancer cohort. Our results are of special importance against the background that CK19 positive carcinomas revealed a significantly poorer prognosis and therefore emphasize its prognostic and possible diagnostic role in tongue cancer.

KEYWORDS:

Ki-67; cytokeratin 19 (CK19); head and neck cancer (HNC); tongue cancer

PMID:
27764819
PMCID:
PMC5342803
DOI:
10.18632/oncotarget.12691
[Indexed for MEDLINE]
Free PMC Article

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