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Climacteric. 2016 Dec;19(6):581-587. Epub 2016 Oct 20.

A negative view of menopause: does the type of symptom matter?

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a Women's Health Clinic, Division of General Internal Medicine , Mayo Clinic , Rochester , MN , USA.
b Biomedical Statistics and Informatics, Division of Health Sciences Research , Mayo Clinic , Rochester , MN , USA.



To assess the association between the type of symptom and women's self-reported view of menopause.


The study was conducted at Mayo Clinic, Rochester MN, between January 2006 and October 2014. Women aged 40-64 were included. Data from 1420 women were analyzed in a cross-sectional design. The Menopause Health Questionnaire was used for symptom assessment. Odds ratios (ORs) and population attributable risk (PAR) (OR × percent frequency) were calculated for each symptom. Logistic regression analyses were performed with the view of menopause as the dependent variable.


Anxiety (2.34), depressed mood (2.24), irritability (2.22), vaginal itching (2.27), crying spells (2.1) and breast tenderness (2.08) were associated with highest odds of having a negative view of menopause. Highest PAR (population impact) symptoms were anxiety (22.27), weight gain (20.66), fatigue (20.28) and irritability (19.41). Hot flushes and night sweats, although common, were not associated with a negative view of menopause (OR 1.3 and 1.16; PAR 3.85 and 4.42, respectively).


Mood symptoms, vaginal itching, weight gain, breast tenderness and fatigue, although less common than hot flushes, were noted to have greater association with a negative view of menopause. Specifically addressing these symptoms during menopausal consultation may improve patient satisfaction and outcomes.


Hot flush; menopausal symptoms; menopause; symptom bother; vasomotor symptoms; view of menopause

[Indexed for MEDLINE]

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