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Molecules. 2016 Oct 17;21(10). pii: E1385.

New Sesquiterpenoids and Anti-Platelet Aggregation Constituents from the Rhizomes of Curcuma zedoaria.

Author information

1
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. jjchen@tajen.edu.tw.
2
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan. jjchen@tajen.edu.tw.
3
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. jjc5711@yahoo.com.tw.
4
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. liaoch@mail.cgu.edu.tw.
5
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. icupdrab@gmail.com.
6
Department of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813, Taiwan. icupdrab@gmail.com.
7
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan. kuoyh@mail.cmu.edu.tw.
8
Department of Biotechnology, Asia University, Taichung 413, Taiwan. kuoyh@mail.cmu.edu.tw.
9
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
10
Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan. chunlinchen@mail.nsysu.edu.tw.
11
Department of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813, Taiwan. pharmacist@ngh.com.tw.

Abstract

Two new sesquiterpenoids-13-hydroxycurzerenone (1) and 1-oxocurzerenone (2)-have been isolated from the rhizomes of Curcuma zedoaria, together with 13 known compounds (3-15). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 13-hydroxycurzerenone (1), 1-oxocurzerenone (2), curzerenone (3), germacrone (4), curcolone (5), procurcumenol (6), ermanin (7), curcumin (8), and a mixture of stigmast-4-en-3,6-dione (12) and stigmasta-4,22-dien-3,6-dione (13) exhibited inhibition (with inhibition % in the range of 21.28%-67.58%) against collagen-induced platelet aggregation at 100 μM. Compounds 1, 5, 7, 8, and the mixture of 12 and 13 inhibited arachidonic acid (AA)-induced platelet aggregation at 100 μM with inhibition % in the range of 23.44%-95.36%.

KEYWORDS:

Curcuma zedoaria; Zingiberaceae; anti-platelet aggregation; rhizomes; sesquiterpenoids

PMID:
27763530
PMCID:
PMC6272984
DOI:
10.3390/molecules21101385
[Indexed for MEDLINE]
Free PMC Article

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